Dose-response effects of oral guanidinoacetic acid on serum creatine, homocysteine and B vitamins levels

    Authors

    S. M. Ostojic; M. Stojanovic; P. Drid;J. R. Hoffman

    Comments

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    Abbreviated Journal Title

    Eur. J. Nutr.

    Keywords

    Creatine; Creatinine; Bioenergetics; Homocysteine; Supplementation; PHYSICAL-ACTIVITY; METABOLISM; HYPERHOMOCYSTEINEMIA; DEFICIENCIES; NUTRITION; PROFILES; ARGININE; DISEASE; BETAINE; HUMANS; Nutrition & Dietetics

    Abstract

    Guanidinoacetic acid (GAA) is an intermediate in the biosynthesis of creatine (Cr), yet its use in human nutrition is limited due to a lack of a clear understanding of its' dose-response effect. Thus, the purpose of this study was to investigate the effect of three different dosages of GAA (1.2, 2.4 and 4.8 g/day) administered for 6 weeks on serum and urinary variables related to GAA metabolism. Forty-eight healthy volunteers participated in the randomized, placebo-controlled, double-blind, repeated-measure study. At baseline, after 1, 2, 4 and 6 weeks, participants provided both fasting blood samples and 24-h urine. GAA intervention significantly increased serum and urinary GAA, Cr and creatinine as compared to placebo (P < 0.05). Differences were found for serum GAA and Cr responses between the three GAA dosages, with high-dose GAA resulting in a greater increase (P < 0.05) in the plasma concentration of both variables as compared to other GAA dosages. In GAA groups, fasting plasma total homocysteine (T-Hcy) increased by 3.5 mu mol/L on average at post-administration, yet no dose-response differences were found between trials. Serum B vitamins were not affected by either placebo or GAA intervention (P > 0.05). Results indicate that low-to-high dosages of exogenous GAA can increase serum concentrations of Cr and T-Hcy while not depleting the B vitamins pool available for remethylation of homocysteine. Clinical trial registration: ClinicalTrials.gov, identification number NCT01133899.

    Journal Title

    European Journal of Nutrition

    Volume

    53

    Issue/Number

    8

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    1637

    Last Page

    1643

    WOS Identifier

    WOS:000345373500005

    ISSN

    1436-6207

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