Title

Characterization of liposomes and silica nanoparticles using resistive pulse method

Authors

Authors

Y. Ruthevich; Y. Q. Lin; A. Wearne; A. Ordonez; O. Lupan;L. Chow

Comments

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Abbreviated Journal Title

Colloid Surf. A-Physicochem. Eng. Asp.

Keywords

Nanoparticles; Electrophoresis; Nanopores; Liposomes; Translocations; Nanopipette; COULTER-COUNTER; PARTICLES; DNA; TRANSPORT; NANOPORES; SIZE; Chemistry, Physical

Abstract

The ability to precisely count inorganic and organic nanoparticles and to measure their size distribution plays a major role in various applications such as drug delivery, nanoparticles counting, and many others. Here we employ a simple resistive pulse method that allows translocations, counting, and measuring size and velocity distribution of silica nanoparticles and liposomes with diameters from 50 nm to 250 nm. This technique is based on the Coulter counter technique but has nanometer size pores. It was found that ionic current drops when nanoparticles enter the nanopore of a pulled micropipette, producing a clear translocation signal. Pulled borosilicate micropipettes with opening 50-350 nm were used as the detecting instrument. This method provides a direct, fast and cost-effective way to characterize inorganic and organic nanoparticles in a solution. (C) 2014 Elsevier B.V. All rights reserved.

Journal Title

Colloids and Surfaces a-Physicochemical and Engineering Aspects

Volume

448

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

9

Last Page

15

WOS Identifier

WOS:000334141100002

ISSN

0927-7757

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