Title
Core-binding factor acute myeloid leukemia: Heterogeneity, monitoring, and therapy
Abbreviated Journal Title
Am. J. Hematol.
Keywords
ACUTE MYELOGENOUS LEUKEMIA; HIGH-DOSE CYTARABINE; MINIMAL RESIDUAL; DISEASE; MYOSIN HEAVY-CHAIN; STEM-CELL TRANSPLANTATION; RECEPTOR; TYROSINE KINASE; HISTONE DEACETYLASE INHIBITORS; ACUTE MYELOMONOCYTIC; LEUKEMIA; INTERNAL TANDEM DUPLICATION; FETAL LIVER HEMATOPOIESIS; Hematology
Abstract
Core binding factor acute myelogenous leukemia (CBF AML) constitutes 15% of adult AML and carries an overall good prognosis. CBF AML encodes two recurrent cytogentic abnormalities referred to as t(8;21) and inv (16). The two CBF AML entities are usually grouped together but there is a considerable clinical, pathologic and molecular heterogeneity within this group of diseases. Recent and ongoing studies are addressing the molecular heterogeneity, minimal residual disease and targeted therapies to improve the outcome of CBF AML. In this article, we present a comprehensive review about CBF AML with emphasis on molecular heterogeneity and new therapeutic options. Am. J. Hematol. 89:1121-1131, 2014. (c) 2014 Wiley Periodicals, Inc.
Journal Title
American Journal of Hematology
Volume
89
Issue/Number
12
Publication Date
1-1-2014
Document Type
Review
DOI Link
Language
English
First Page
1121
Last Page
1131
WOS Identifier
ISSN
0361-8609
Recommended Citation
"Core-binding factor acute myeloid leukemia: Heterogeneity, monitoring, and therapy" (2014). Faculty Bibliography 2010s. 6108.
https://stars.library.ucf.edu/facultybib2010/6108
Comments
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