Title

Modeling the Potential Role of Inactivated Poliovirus Vaccine to Manage the Risks of Oral Poliovirus Vaccine Cessation

Authors

Authors

R. J. D. Tebbens;K. M. Thompson

Comments

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Abbreviated Journal Title

J. Infect. Dis.

Keywords

polio; eradication; dynamic modeling; disease outbreaks; inactivated; poliovirus vaccine; oral poliovirus vaccine; PARALYTIC POLIOMYELITIS; UNITED-STATES; TRANSMISSION; ERADICATION; IMMUNITY; ENDGAME; POLICY; IMMUNOGENICITY; SEROPREVALENCE; COMMUNITY; Immunology; Infectious Diseases; Microbiology

Abstract

Background. The Global Polio Eradication Initiative plans to stop all oral poliovirus vaccine (OPV) after wild poliovirus eradication, starting with serotype 2. Stakeholders continue to discuss the role of using inactivated poliovirus vaccine (IPV) to manage the risks of circulating vaccine-derived polioviruses (cVDPVs) during the end game. Methods.aEuro integral We use a poliovirus transmission and OPV evolution model to explore the impact of various routine immunization policies involving IPV on population immunity dynamics and the probability and magnitude of cVDPV emergences following OPV cessation. Results.aEuro integral Adding a single IPV dose to an OPV-only routine immunization schedule at or just before OPV cessation produces very limited impact on the probability of cVDPV emergences and the number of expected polio cases in settings in which we expect cVDPVs in the absence of IPV use. The highest-cost option of switching to a 3-dose IPV schedule only marginally decreases cVDPV risks. Discontinuing supplemental immunization activities while introducing IPV prior to OPV cessation leads to an increase in cVDPV risks. Conclusions.aEuro integral Introducing a dose of IPV in countries currently using OPV only for routine immunization offers protection from paralysis to successfully vaccinated recipients, but it does little to protect high-risk populations from cVDPV risks.

Journal Title

Journal of Infectious Diseases

Volume

210

Publication Date

1-1-2014

Document Type

Article

Language

English

First Page

S485

Last Page

S497

WOS Identifier

WOS:000344612400058

ISSN

0022-1899

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