Title

Disease invasion on community networks with environmental pathogen movement

Authors

Authors

J. H. Tien; Z. S. Shuai; M. C. Eisenberg;P. van den Driessche

Comments

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Abbreviated Journal Title

J. Math. Biol.

Keywords

Cholera; Waterborne disease; Basic reproduction number; Spanning trees; Group inverse; CHOLERA; EPIDEMIC; DYNAMICS; HAITI; MODELS; ORIGIN; WORLD; Biology; Mathematical & Computational Biology

Abstract

The ability of disease to invade a community network that is connected by environmental pathogen movement is examined. Each community is modeled by a susceptible-infectious-recovered (SIR) framework that includes an environmental pathogen reservoir, and the communities are connected by pathogen movement on a strongly connected, weighted, directed graph. Disease invasibility is determined by the basic reproduction number for the domain. The domain is computed through a Laurent series expansion, with perturbation parameter corresponding to the ratio of the pathogen decay rate to the rate of water movement. When movement is fast relative to decay, is determined by the product of two weighted averages of the community characteristics. The weights in these averages correspond to the network structure through the rooted spanning trees of the weighted, directed graph. Clustering of disease "hot spots" influences disease invasibility. In particular, clustering hot spots together according to a generalization of the group inverse of the Laplacian matrix facilitates disease invasion.

Journal Title

Journal of Mathematical Biology

Volume

70

Issue/Number

5

Publication Date

1-1-2015

Document Type

Article

Language

English

First Page

1065

Last Page

1092

WOS Identifier

WOS:000351175300004

ISSN

0303-6812

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