A Series of Fluorene-Based Two-Photon Absorbing Molecules: Synthesis, Linear and Nonlinear Characterization, and Bioimaging

    Authors

    C. D. Andrade; C. O. Yanez; L. Rodriguez;K. D. Belfield

    Comments

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    Abbreviated Journal Title

    J. Org. Chem.

    Keywords

    PHOTOPHYSICAL PROPERTIES; OPTICAL-PROPERTIES; FLUORESCENCE; DERIVATIVES; ABSORPTION; DESIGN; MICROFABRICATION; CHROMOPHORES; DYES; Chemistry, Organic

    Abstract

    The synthesis, structural, and photophysical characterization of a series of new fluorescent donor acceptor and acceptor-acceptor molecules, based on the fluorenyl ring system, with two-photon absorbing properties is described. These new compounds exhibited large Stokes shifts, high fluorescence quantum yields, and significantly, high two-photon absorption cross sections, making them well suited for two-photon fluorescence microscopy imaging. Confocal and two-photon fluorescence microscopy imaging of COS-7 and HCT 116 cells incubated with probe I showed endosomal selectivity, demonstrating the potential of this class of fluorescent probes in multiphoton fluorescence microscopy.

    Journal Title

    Journal of Organic Chemistry

    Volume

    75

    Issue/Number

    12

    Publication Date

    1-1-2010

    Document Type

    Article

    Language

    English

    First Page

    3975

    Last Page

    3982

    WOS Identifier

    WOS:000278560700005

    ISSN

    0022-3263

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