Title

A Series of Fluorene-Based Two-Photon Absorbing Molecules: Synthesis, Linear and Nonlinear Characterization, and Bioimaging

Authors

Authors

C. D. Andrade; C. O. Yanez; L. Rodriguez;K. D. Belfield

Comments

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Abbreviated Journal Title

J. Org. Chem.

Keywords

PHOTOPHYSICAL PROPERTIES; OPTICAL-PROPERTIES; FLUORESCENCE; DERIVATIVES; ABSORPTION; DESIGN; MICROFABRICATION; CHROMOPHORES; DYES; Chemistry, Organic

Abstract

The synthesis, structural, and photophysical characterization of a series of new fluorescent donor acceptor and acceptor-acceptor molecules, based on the fluorenyl ring system, with two-photon absorbing properties is described. These new compounds exhibited large Stokes shifts, high fluorescence quantum yields, and significantly, high two-photon absorption cross sections, making them well suited for two-photon fluorescence microscopy imaging. Confocal and two-photon fluorescence microscopy imaging of COS-7 and HCT 116 cells incubated with probe I showed endosomal selectivity, demonstrating the potential of this class of fluorescent probes in multiphoton fluorescence microscopy.

Journal Title

Journal of Organic Chemistry

Volume

75

Issue/Number

12

Publication Date

1-1-2010

Document Type

Article

Language

English

First Page

3975

Last Page

3982

WOS Identifier

WOS:000278560700005

ISSN

0022-3263

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