Low-Dose Prednisone or Methylprednisolone in Treating Patients With​ Newly Diagnosed Acute GVHD​

Authors

Dillon C. Hill, University of Central FloridaFollow
Melanie Obsina, University of Central FloridaFollow
Juan Sanchez, University of Central FloridaFollow
Jordan Genco, University of Central FloridaFollow
Vihan Yalamanchili, University of Central FloridaFollow

Streaming Media

Files

Course Code

HSC

Course Number

4930

Faculty/Instructor

Professor Steven Burroughs

Faculty/Instructor Email

steven.burroughs@ucf.edu

About the Author

We are a group of seniors in Health Sciences. This presentation is based on work completed within Health Sciences Seminar under our professor Steven Burroughs. He was a great help with the completion of our project. He met with us multiple times and gave us extensive suggestions of how to improve our work and best communicate our points. We would like to thank our fellow classmates who complimented the work we had completed. They helped motivate us to participate in this showcase and share what we have learned.

Abstract, Summary, or Creative Statement

Graft Versus Host Disease affects less than 20,000 cases per year and our project aims to give those who experience this terrible disease a better outcome and more manageable pain. The clinical trial that this data is collected from analyzes low-dose prednisone versus the standard dose and how that affects both morbidity and progression of the disease to Stage III-IV. This clinical trial has many clinical implications as it shows that reducing the dosage of commonly used treatment methods can sometimes have positive effects even though it is the standard to use a certain dose. This clinical trial found that when reducing the dose of the steroid from 1.0 mg/kg to .5mg/kg the progression rates in the patients participating was nearly half (13% compared to 6%). We made clinical recommendations for this new treatment for different clinical settings based on this information which allowed us to utilize all of the education we have received thus far and apply it to clinical situations. We have learned how to better differentiate treatment options based on the current condition and environment of patients. We have also learned how to communicate our recommendations through presenting detailed histories of a disease, mechanisms of actions of medications or treatments, and by providing an in-depth analysis of clinical trial data to an audience that will provide recommendations of treatment based on our presentation.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Keywords

Clinical Trial; Healthcare; Disease; Medications; Treatments; Progression; Steroid; Graft Versus Host Disease; GVHD

Recommended Citation

Hill, Dillon C.; Obsina, Melanie; Sanchez, Juan; Genco, Jordan; and Yalamanchili, Vihan, "Low-Dose Prednisone or Methylprednisolone in Treating Patients With​ Newly Diagnosed Acute GVHD​" (2023). High Impact Practices Student Showcase Fall 2023. 31.
https://stars.library.ucf.edu/hip-2023fall/31