TxtE is a protein related to cytochrome P450 enzymes, which catalyze a number of reactions that typically involve oxygen and not nitrogen. It has been discovered that TxtE can nitrate tryptophan through an unusual reaction in which it uses nitric oxide (NO) as a nitrogen donor to install the nitro group despite NO typically being considered toxic to bacteria. This project will determine if all cytochromes P450 can catalyze nitration as long as they are given NO. This will have an impact on understanding drug delivery and metabolism for which nitration is important.
Bachelor of Science (B.S.)
College of Sciences
Johnson, Lannika, "Investigation of Catalysis of Nitration by Cytochrome P450s" (2022). Honors Undergraduate Theses. 1154.