Abstract

TxtE is a protein related to cytochrome P450 enzymes, which catalyze a number of reactions that typically involve oxygen and not nitrogen. It has been discovered that TxtE can nitrate tryptophan through an unusual reaction in which it uses nitric oxide (NO) as a nitrogen donor to install the nitro group despite NO typically being considered toxic to bacteria. This project will determine if all cytochromes P450 can catalyze nitration as long as they are given NO. This will have an impact on understanding drug delivery and metabolism for which nitration is important.

Thesis Completion

2022

Semester

Spring

Thesis Chair

Caranto, Jonathan

Degree

Bachelor of Science (B.S.)

College

College of Sciences

Department

Chemistry

Degree Program

Biochemistry

Language

English

Access Status

Open Access

Release Date

5-1-2022

Restricted to the UCF community until 5-1-2022; it will then be open access.

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