In summary, this study will be focused on Il-21 and its implications in the antibody response in influenza. The isotype classes primarily involved in this process will also be examined. This will be accomplished by looking at the serum of mice and analyzing the present influenza specific antibodies using ELISA. Another goal was to optimize the ELISA in order to make it sensitive enough to catch small differences in the results. This topic is important due to its implications for improving influenza vaccinations and preventions as current vaccines are not 100% effective. Influenza contributes to significant disease and death around the world every year and each piece of this puzzle is significant in order for the scientific community to be able to eventually make strides to improve the burden of this disease.
Bachelor of Science (B.S.)
College of Medicine
Immunity and Pathogenesis
Gallahan, Samantha E., "Exploring Interleukin 21 and Its Role in Humoral Immunity in the Mouse Model of Influenza Infection" (2021). Honors Undergraduate Theses. 873.