Abstract
Despite improved life expectancy compared to medical management alone, Ventricular Assist Device (VAD) recipients show survival rates of 80% at 12 months and 70% at 24 months. A large portion of VAD-associated mortality results from increased risk of stroke with an event frequency reported between 14-47%. Recent concerns have been raised about unprecedented increases of thrombus formation in VAD recipients with subsequent reports pointing towards implantation techniques as a critical contributor to these events. Thus, the overall prognosis with mechanical support can improve by advancing the surgeon’s approach to VAD implantation. Previous studies using Computational Fluid Dynamics (CFD) were aimed at reducing stroke rates by tailoring the VAD outflow graft (VAD-OG) angle to direct any circulating emboli away from the cerebral vessels. In-vitro, or benchtop, models are often developed as computational counterparts. In order to accurately model the hemodynamics in the cardiovascular system, pulsatile flow must be mimicked. This is achieved in the computational domain by what is called a Windkessel model. This project seeks to develop a physical analogy to the Windkessel model for use in the benchtop experiments.
Notes
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Thesis Completion
2015
Semester
Fall
Advisor
Kassab, Alain
Degree
Bachelor of Science in Mechanical Engineering (B.S.M.E.)
College
College of Engineering and Computer Science
Department
Mechanical and Aerospace Engineering
Degree Program
Mechanical Engineering
Subjects
Dissertations, Academic -- Engineering and Computer Science; Engineering and Computer Science -- Dissertations, Academic
Format
Identifier
CFH0004894
Language
English
Access Status
Open Access
Length of Campus-only Access
None
Document Type
Honors in the Major Thesis
Recommended Citation
Beggs, Kyle W., "Design of a Physical Windkessel Model for Use in LVAD In-vitro Benchtop Modeling" (2015). HIM 1990-2015. 1854.
https://stars.library.ucf.edu/honorstheses1990-2015/1854