The Role Of Micrornas In Cellular Senescence, Inflammation, And Cancer Induced By Childhood Obesity

Author

Sarah S. Siddiqi, University of Central FloridaFollow

Keywords

Childhood Obesity; Cellular Senescence; Inflammation; Cancer; Bariatric Surgery; MicroRNA

Abstract

Childhood obesity has escalated into a major public health crisis with serious implications for long-term health. As obesity rates among children continue to rise globally, it is crucial to understand its effects on cellular aging and inflammation—key processes that underpin many metabolic diseases. Obesity not only directly contributes to various metabolic disorders but also disrupts fundamental cellular mechanisms, accelerating aging and fostering systemic inflammation. By examining the impact of obesity on cellular aging and chronic inflammation, as well as the regulatory role of microRNAs (miRNAs) in these pathways, we have been able to identify critical biomarkers and molecular mechanisms involved in accelerated aging and persistent inflammation in obese children. Our research explores how obesity-induced alterations in cellular senescence and inflammation contribute to the broader spectrum of obesity-related health issues and lead to a potential predisposition for cancer. By investigating the expression and function of specific miRNAs that regulate these processes, we are able to elucidate the underlying mechanisms driving these complications. The insights gained from this study are expected to enhance public health strategies by providing a comprehensive understanding of the cellular and molecular factors associated with childhood obesity. Ultimately, this research will contribute to the development of more effective preventative and therapeutic approaches, aiming to improve health outcomes and quality of life for children affected by obesity.

Thesis Completion Year

2024

Thesis Completion Semester

Fall

Thesis Chair

Masternak, Michal

College

College of Medicine

Department

Burnett School of Biomedical Sciences

Thesis Discipline

Biomedical Sciences

Language

English

Access Status

Open Access

Length of Campus Access

None

Campus Location

Orlando (Main) Campus

STARS Citation

Siddiqi, Sarah S., "The Role Of Micrornas In Cellular Senescence, Inflammation, And Cancer Induced By Childhood Obesity" (2024). Honors Undergraduate Theses. 173.
https://stars.library.ucf.edu/hut2024/173