Keywords
Acne vulgaris; Isotretinoin; Accutane; Quality of life; Systematic review; Risk-benefit analysis
Abstract
Acne vulgaris is a prevalent dermatological condition, particularly affecting adolescents and young adults. While often treated as a cosmetic issue, acne can significantly impair a patient's mental health and overall quality of life (QoL). Isotretinoin, commonly known as Accutane, is widely regarded as the most effective treatment for severe and persistent acne. However, its use is controversial due to a range of potential side effects, including psychiatric symptoms, teratogenicity, and other systemic complications. To better understand the risk-benefit profile of isotretinoin in acne treatment, we conducted a systematic review, focusing on the QoL benefits and risks associated with its use. Studies were selected through a comprehensive screening process following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of included studies was assessed using the Newcastle-Ottawa Scale (NOS) for nonrandomized studies, such as case-control and cohort designs. Of the studies reviewed, several demonstrated significant improvements in patients’ QoL due to reduced acne severity, while others highlighted the risks, particularly in terms of mental health side effects. Our findings reveal that while isotretinoin significantly enhances QoL in many patients, it also carries a substantial risk for adverse effects. This review provides valuable insights for healthcare professionals when considering isotretinoin as a treatment option, emphasizing the need for close monitoring of patients during and after treatment.
Thesis Completion Year
2025
Thesis Completion Semester
Spring
Thesis Chair
Ahangari, Raheleh
College
College of Medicine
Department
Burnett School of Biomedical Sciences
Thesis Discipline
Biomedical Sciences
Language
English
Access Status
Open Access
Length of Campus Access
None
Campus Location
Orlando (Main) Campus
STARS Citation
Valencia Zuniga, Noelia, "The Quality-of-Life Benefits and Risk of Isotretinoin (Accutane) in Acne Treatment: A Systematic Review" (2025). Honors Undergraduate Theses. 248.
https://stars.library.ucf.edu/hut2024/248
Included in
Dermatology Commons, Mental Disorders Commons, Psychiatric and Mental Health Commons, Skin and Connective Tissue Diseases Commons
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