Keywords

electrospray encapsulator; cerium oxide; sodium alginate; calcium chloride; reactive oxygen species; controlled release

Abstract

This thesis presents the synthesis and characterization of cerium oxide nanoparticles (CNPs), and silver-doped cerium oxide nanoparticles (AgCNPs) loaded in alginate beads that were designed to be applied in biomedical settings. Cerium oxide was chosen for its antioxidant and anti-inflammatory capabilities, and silver oxide was selected to enhance antimicrobial functionality, both of which are pivotal in expedited wound closure and promoting cellular proliferation. Through the use of an advance electrospray encapsulation apparatus, alginate-based polymer beads were created by incorporating either CNPs or AgCNPs into the matrix. These beads were later characterized using a range of microscopic and FTIR analyses, in order to obtain information about chemical makeup and mechanical properties of the bead. After confirming the presence of CeO2 within the alginate matrix, in-vitro studies were conducted in order to evaluate the biological competence of the CeO2-alginate beads. By assessing the controlled release of the ions from the beads, the impact on cellular responses to wound healing can be determined. The integration of these characterization techniques and in-vitro studies seek to establish the chemical and structural attributes of the beads and is predicted to provide crucial insight into wound care and improving clinical outcomes in the biomedical discipline by accelerating the rate of wound healing and minimizing complications.

Thesis Completion Year

2025

Thesis Completion Semester

Spring

Thesis Chair

Seal, Sudipta

College

College of Health Professions and Sciences

Department

Material Science and Engineering

Thesis Discipline

Material Science

Language

English

Access Status

Open Access

Length of Campus Access

None

Campus Location

Orlando (Main) Campus

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Rights Statement

In Copyright