Keywords
Cerium; Wound Healing; Reactive Oxygen Species; Material doping
Abstract
Ceria nanoparticles' capabilities to defend cells against oxidative stress through superoxide dismutase activity are well-documented. Ceria nanoparticles demonstrate a ratio between 3+/4+ oxidative states on the surface of the particles to exhibit oxygen vacancies, a feature that allows these particles to scavenge Reactive Oxygen Species (ROS) in times of Oxidative Stress. Oxidative stress arises from many wounds in the body, such as wounds in the skin, and can have significant impacts on the health of an individual. Even when receiving treatment for the skin wound, ROS can circulate from around the wound, be generated from an imbalance in antioxidants, or enter from the environment. These ROS can further delay the healing of wounds or exacerbate issues, causing irreparable harm to cells and DNA around the wound site. Ceria nanoparticles have been utilized in the past to perform targeted drug delivery into the body and have been vastly investigated for their ability to scavenge ROS. To utilize both the drug-delivery and scavenging aspects of ceria nanoparticles, this paper will investigate the ability of metal-doped ceria nanoparticles to scavenge ROS during times of oxidative stress. The experimentation will involve Gold (Au), Zinc (Zn), Iron (Fe), Copper (Cu), and Strontium (Sr) utilized as the metals for doping the ceria nanoparticles. This topic poses a novel approach to wound healing, as utilizing a dual-use approach to CNP drug delivery can provide significant therapeutic advances.
Thesis Completion Year
2025
Thesis Completion Semester
Spring
Thesis Chair
Seal, Sudipta
College
College of Engineering and Computer Science
Department
Materials Science and Engineering
Thesis Discipline
Materials Science
Language
English
Access Status
Open Access
Length of Campus Access
None
Campus Location
Orlando (Main) Campus
STARS Citation
Mittal, Agastya, "Effect Of Metal Ions On The Reactive Oxygen Species Scavenging Capabilities Of Cerium Oxide For Biological Applications" (2025). Honors Undergraduate Theses. 269.
https://stars.library.ucf.edu/hut2024/269
Rights Statement
