Keywords

cardiovascular disease; HIV; comorbidities; metabolism; Tg26; indirect calorimetry

Abstract

Obesity and related comorbidities, such as cardiovascular disease, have been increasing globally, with more than two-thirds of the 4.0 million deaths in 2015 caused by cardiovascular disease (Powell-Wiley, 2021). With the global obesity epidemic and related comorbidities, including cardiovascular disease, increasing every year, it has become crucial to ensure that we target high risk populations. A recent analysis found that people living with HIV have more than twice the risk of cardiovascular disease, compared to those without HIV (So-Armah et al., 2020). This study will compare metabolic differences across genders and genotypes in mature Tg26 transgenic mice via indirect calorimetry. We hypothesize that Tg26 mice will exhibit lower RERs due to their reduced ability to utilize carbohydrates in early ages, with decreasing effects with age and greater kidney injury and muscle wasting. This study will improve our understanding of gender and age-related metabolic changes associated with people living with HIV.

Thesis Completion Year

2025

Thesis Completion Semester

Spring

Thesis Chair

Gupta, Manish

College

College of Medicine

Department

Burnett School of Biomedical Sciences

Thesis Discipline

Biomedical Sciences

Language

English

Access Status

Campus Access

Length of Campus Access

5 years

Campus Location

Orlando (Main) Campus

Subjects

HIV infections--Animal models; Mice--Metabolism; HIV infections--Research; Obesity--Animal models; HIV infections--Complications

Download

Restricted to the UCF community until 5-15-2030; it will then be open access.

Supplemental Files

Share

COinS
 

Accessibility Statement

This item was created or digitized prior to April 24, 2027, or is a reproduction of legacy media created before that date. It is preserved in its original, unmodified state specifically for research, reference, or historical recordkeeping. In accordance with the ADA Title II Final Rule, the University Libraries provides accessible versions of archival materials upon request. To request an accommodation for this item, please submit an accessibility request form.

Rights Statement

In Copyright