Keywords

urothelial bladder carcinoma; survival analysis; functional annotation clustering; cbioportal; oncogenesis; genomics

Abstract

Urothelial bladder carcinoma is a disease affecting approximately 85,000 new people each year. The molecular profile for bladder cancer cases is diverse, with special attention given to the differences between males and females due to males being approximately four times more likely to be diagnosed with this disease. This thesis identifies significantly altered genes and significantly expressed genes between males and females diagnosed with urothelial bladder carcinoma by synthesizing data from numerous open-source databases and analyzing how DNA alterations, gene expression patterns and environmental risk factors influence survival outcomes across males and females. The results suggest that alterations to genes coding for cyclin-dependent kinase inhibitors are associated with significantly worse five-year overall survival outcomes for both males and females. KDM6A, a known tumor suppressor commonly altered in bladder cancer, and FGFR3, an oncogene that is also commonly altered in bladder cancer, were associated with better five-year overall survival outcomes in males only, suggesting potential targetability/response to existing therapeutics. This meta-analysis provides insight into the genetic differences between males and females with urothelial bladder carcinoma, while shining a light on two of the most altered genes associated with this disease.

Thesis Completion Year

2025

Thesis Completion Semester

Fall

Thesis Chair

Khaled, Annette

College

College of Medicine

Department

Burnett School of Biomedical Sciences

Thesis Discipline

Biomedical Sciences

Language

English

Access Status

Campus Access

Length of Campus Access

1 year

Campus Location

Orlando (Main) Campus

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Restricted to the UCF community until 12-15-2026; it will then be open access.

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Rights Statement

In Copyright