A collection of Medicine Masters Theses and Doctoral Dissertations.

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Theses/Dissertations from 2025

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Exploring Senescence For Improved Diagnosis And Treatment In Head And Neck Cancer, Md Tanjim Alam

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Targeting Il-6 Signaling And Release Pathways Modulates Inflammation And Restores Intestinal Epithelial Integrity And Function During Mycobacterium Avium Paratuberculosis Infection, Ala' Mahmoud Saleem Alhendi

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Upregulation of Reactive Oxygen Species Induces Cell Death in Cisplatin-Induced Cardiotoxicity, Caitlin M. Beech

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Investigating the role of selenium-dependent Stickland reactions in Clostridioides difficile bioenergetics, Dominika Dzurny

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Optimized Encapsulation of Oxytetracycline-Divalent Cations Complex for Sustained Antibacterial Activity against Escherichia coli and Staphylococcus aureus, Cecilia Ezeanya

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Establishment of an HIV Cell Model to Study Latent Virus-Induced Oxidative Stress, Nicole Ford

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Inhibition of Activin A Signaling Slows the Progression of Barrett's Esophagus Induced Esophageal Adenocarcinoma, Lily A. Giardino

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Differential Interferon Synthesis and Signaling Between Parainfluenza Virus Acute and Persistently Infected Cells, Vonisha Kaigler

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Interactions Of Anti-Viral Ceria Nanoparticles With An Enveloped RNA Virus, Muhammad Hassan Mehmood Kalyar

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Synthesis and Evaluation of Chalcones as Treatment for Negative Sense Single Stranded RNA Viruses and Applications as Broad-Spectrum Antivirals, Lorael Kirton

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Distribution and Morphology of Spinal Afferent Innervation of the Gastric Muscular and Submucosal Layers of Rats: Anterograde Tracing, Andrew M. Kwiat

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The Multifaceted Roles of Propionic Acid in Autism Spectrum Disorder and Crohn’s Disease, Piotr P. Lagod

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Molecular Basis for the Disaggregase Activity of Protein Disulfide Isomerase, Antonio Mele

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IL-2 Receptor Expression During Influenza A Virus Infection: Kinetics and Consequences, James N. Menefee III

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Active Immunization against Myostatin and Activin A: A Therapeutic Strategy for Sarcopenia, Mishfak Abdullah Mohamed Mansoor

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Assessment of Biological and Physicochemical Properties of Stabilized Curcumin-Borate Complexes Through Nanoparticle Loading, Umar Mohammad

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Mapping the Nociceptive and Spinal Afferent Innervation of a Rodent Stomach onto a 3D Organ Scaffold, Duyen Nguyen

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FGF19 Facilitates Metastatic Phenotypes in Colorectal Cancer, Joseph W. Nolff

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Exploring the Role of Fatty Acid Signaling in Macrophages, Ayomide Ogunsanmi

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Discovery of Antiplasmodial Compounds Using Ring Distortion on Alkaloids, Raphaella A. Paes

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Development of Human Neuronal Microphysiological Models and Subsequent Integration into Multi-Organ Platforms for Evaluation of Therapeutic Efficacy and Off-Target Toxicity, Aakash Patel

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Mechanistic Insights into the Antimicrobial Action of Fungus-Derived Xanthoquinodins against Clostridioides difficile, Erika A. Serravalle

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Roles of IFN-Alpha/Beta and IFN-Gamma in Enhancing and Inhibiting NK Cell Mediated Killing of Oncolytic Virus Infected Tumor Cells, Elisabeth M. Shiffer

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Multi-omics analysis of streptococcus pneumoniae serotype 3 using a murine infection model, Jash Kamlesh Trivedi

Theses/Dissertations from 2024

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Cisplatin Induces Skeletal Muscle Toxicity and Adverse Muscle Remodeling Via Pyroptotic Cell Death, Chisom Nkemdirim Akaniru

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Epidemiological Insights of Covid-19: Understanding Variant Dynamics, Environmental Surveillance and Disparities in Florida, Md Sobur Ali

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Investigating Natural Proline-rich Antimicrobial Peptides (PrAMPs) Activity Towards Klebsiella pneumoniae, Ridhwana M. Appiah

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The Role of Cellular Senescence in Inflammatory Bowel Diseases (IBDs), Sarah A. Ashiqueali

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Cardiac and Skeletal Muscle Dysfunction in Diabetic Dyslipdemic mice is Mitigated by Stem Cell Derived Exosomes, Abha Banerjee

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Structural Characterization of Spinal Afferents in the Male Rat Heart Using Anterograde Tracing, Kayla Barton

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Distribution and Morphology of CGRP-IR Axons in Flat-Mounts of Whole Rat Hearts and Whole Male/Female Mouse Atria, Kohlton T. Bendowski

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Defining the roles of BlaRI orthologs in Mycobacterium abscessus, Lauren E. Bonefont

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Exploring the Mechanism of Chaperonin-Containing TCP-1 (CCT) as a Cancer Therapeutic, Carolyn K. Dang

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Investigating The Role Of Chaperonin Containing TCP-1 In Extracellular Vesicles Isolated From Breast And Prostate Cancer Cell Lines, Colten J. Frank

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Application of Long-Read Sequencing in Microbiome Compositional Studies related to Disease, Noah Greenman

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Developing a Novel Gold Nanoparticle-based Colorimetric Assay for the Detection of Cytomegalovirus (CMV) in Pediatric-derived Urine Specimens, Sonam Gupta

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Development of a Novel Mitochondria Biosensor, Randall K. James

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Exploring the Physiology of Clostridioides difficile: Selenium-Dependent Catabolism of Host-Derived Nutrients, Michael A. Johnstone

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The Role of Adiponectin in Gustatory Perception of Fat, Fangjun Lin

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Aquaporin 4 promotes Drug Tolerance to AMG 510 in KRASG12C mutant Non-Small Cell Lung Cancer, Nastassja G. Luna

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Probing Endothelial-to-Mesenchymal Transition Cellular Biomechanics, Marvin A. Mendoza Jr

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Synthesis and Bioevaluation of Piperazine-based Compounds as Anti-cancer Agents in Pancreatic Cancer, Holly E. Moots

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Effect of Acetate and Cell Density on External Proton Supply for Chlamydomonas reinhardtii Biohydrogen Production, Keval V. Patel

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Investigating Lectin Mannose Binding 1 (LMAN1) as a Potential Regulator of Inflammatory Responses in Alternaria alternata-Induced Allergic Asthma, Faith Sauber

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A paradoxical tale: Sodium taurocholate counteracts bactericidal potency of Silver-modified cerium oxide nanoparticle (AgCNP), a sporicidal disinfectant against C. difficile on abiotic surfaces, Deepa Shah

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Adaptation to Hypoxia and Nitrate/Nitrite Assimilation Require Species-Specific Regulation by DosR and NnaR in Mycobacterium abscessus, Breven S. Simcox

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Silencing stemness genes in Glioblastoma cancer stem cells improve anticancer drug efficacy, Jonhoi C. Smith

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Mycobacterium Avium Paratuberculosis Infection Suppresses Vitamin D Activation and Cathelicidin Production in Macrophages Through Modulation of the TLR2-dependent p38/MAPK-CYP27B1-VDR-CAMP Axis, Muna M. Talafha

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Identification of the Role of Protein Kinases in VLDL Trafficking, Fahim Rejanur Tasin

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Inhibitors of Amyloid Beta Oligomerization and Toxicity, Maria C. Zabala Rodriguez

Theses/Dissertations from 2023

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Mesenchymal Stem Cell Derived Exosomes Attenuates Doxorubicin-Induced Cardiotoxicity, Sawdah A. Ali

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Ponatinib-induced Cardiac Toxicity is Mediated by Impaired Angiogenesis, Imran Altiokka

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Topographical Distribution and Morphology of Sympathetic Postganglionic Innervation and Chronic Intermittent Hypoxia (CIH) Induced Remodeling of the Whole Heart at Single Cell/Axon/Varicosity Scale, Ariege Bizanti

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Repurposing of Human Protein Kinase Inhibitors Identifies Dual Stage Active Antimalarials, Monica J. Bohmer

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Identification and Influence of Species-Informative 16S Ribosomal RNA Sequences and Evaluation of Ocean Biofilms, Nikhil Bose

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Examining the Relationship between phiETA Susceptibility & Temperate Phage Diversity in Staphylococcus aureus, Atrayee Chatterjee

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Examining Novel Aspects of T-cell Priming and Lung Resident T-cell Function to Improve Vaccine Induced Protection Against Influenza A Virus, Caroline M. Finn

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Polyamine Blockade Therapy: Modulating Pancreatic Tumor Microenvironment and Role in MDSC Biology, Manav Gandhi

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Targeting Inhibitory Receptor TIGIT Signaling in NK Cells to Improve Anti-tumor Immunity, Md Faqrul Hasan

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Host Cell Responses Modulate Oncolytic Viral Treatment of Neuroblastoma Cells, Kritika Kedarinath

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Analysis of Acute Colitis in Mice Deficient for Master Regulators of Both Type-1 and Type-17 Inflammation Using Traditional Readouts and Metabolic and Behavioral Data, Rodney Long

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Comprehensive Imaging And Quantitative Analysis Techniques For Nociceptive Afferent Innervation Of The Stomach And Development Of A Micro Liquid Thermal Regulator (MLTR), Jazune Madas

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Identification of an Endogenous Multiprotein Complex Required to Generate the VLDL Transport Vesicle from the Hepatic ER, Rutuparnna Mishra

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Characterization of Snyder-Robinson Syndrome (SRS) in Mutant Mice and Treatment with a Novel Spermine Prodrug to Rebalance Intracellular Polyamine Levels, Deepshikha Mitra

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GATM is Involved in the Promotion of Drug Resistance in Lung Cancer, Nikitha Murugavel

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Mechanisms of Early-Stage Mutant EGFR-Driven Lung Cancer: The Role of Kynurenine, Alice Rodriguez-Fuguet

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Roles of Chlamydia Trachomatis Early Effector Proteins Tarp, TmeA, and TmeB in Host Cytoskeleton Remodeling During Invasion, Kaylyn R. Scanlon-Richardson

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New Tools and Platforms for Mosquito Behavior, Control and Bite-site Biology Investigations, Corey Seavey

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PDI's Function as a Disaggregase Uses a Novel Mechanism of Action, Albert A. Serrano

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Preclinical Assessment of Psychoplastogens for Treatment of Psychiatric Symptoms and Neuroplasticity Deficits in Huntington Disease, Nicholas Skiados

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Mechanisms by Which LMAN1 Regulates HDM-induced Allergic Inflammation, Lindsay Swaby

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Genotypic and Phenotypic Analysis of Pseudomonas aeruginosa from Respiratory Tract of Pediatric Patients, Wageha Talib

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Role of Vitamin D, Folate, and Cobalamin Deficiency in Mycobacterium avium Paratuberculosis Infection and Inflammation, Joseph Vaccaro

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Impact of R300 and C343 in the B' Domain of Protein Disulfide Isomerase on its Disaggregase Activity Against Cholera Toxin, Evie Vincent

Theses/Dissertations from 2022

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Delineating the Cytotoxic Mechanism of Purine Metabolite AICAR in Lung Cancer Cells, Fareesa Aftab

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Extracellular Vesicle-associated Biomolecules as Potential Biomarkers for Alzheimer's Disease Diagnosis, Lina Bedoya Martinez

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Discovery of Antiplasmodial Compounds From Fungi, Jennifer Collins

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Chaperonin Containing TCP-1 is a novel biomarker for cancer detection, Amanda Cox

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3D Microelectrode Arrays (MEAs) For The Study And Interrogation Of Electrogenic Cells In Fabricated Microenvironments, Charles Didier

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Development of Curcumin-loaded Nanoparticles for Drug Delivery Optimization in the Treatment of Peripheral Nerve Injury, Giuliana Giannelli

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Molecular Adaptations for Intestinal Colonization in Vibrio cholerae, Trudy-Ann Grant

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Evaluation of Magnesium Hydroxide Particles Coated with Betaine and Citrate as a Magnesium Delivery System for Migraine Treatment, Ashton Holderness

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Reexamining Cytolethal Distending Toxin's Host Cell Entry and Trafficking: The First Steps Down a Long Road, George Huhn

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Effects of PCSK9i on Doxorubicin Induced Necroptosis, Omonzejie Imaralu

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Functional Based Drug Discovery With Artificial Intelligence, Arash Keshavarzi Arshadi

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Attenuation of Excess TNFα Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGFβ-mediated Immunosuppression Through the Modulation of TACE Trafficking, Taylor Louis

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Reporter Chondrocyte Optimization of Bioinks for Zonal 3D Bioprinting of Cartilage, Kari Martyniak

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Investigating the Relationship Between the Microbiome and Neuroactive Metabolites in Huntington Disease Model Mice, Christian Millot

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Topographical Distribution and Morphology of Substance P Containing Nerves in the Flat-Mounts and Serial Sections of Mouse Whole Stomach at the Single Cell/Axon/Synapse Scale: A Comprehensive Study., Anas Jaser Mousa Mistareehi

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Evaluating Novel Combinations of Polyamine Targeting Therapeutics in Pancreatic Ductal Adenocarcinoma, Sai Preethi Nakkina

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Mapping the Organization and Morphology of Calcitonin Gene-Related Peptide (CGRP)-IR Axons in the Whole Mouse Stomach, Duyen Nguyen

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The Role of Pro-Longevity MicroRNAs in Aging, Sarah Noureddine

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Deciphering the Role and Clinical Application of the FGFR4-KLB-FGF19 Axis in Colorectal Neoplastic Progression, Michael Rohr

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BMP-7 Ameliorates Ponatinib Induced Muscle Cell toxicity: An in vitro and in vivo Study, Ayushi Srivastava

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Virus Mediated Delivery of Signals to Enhance NK Cell Mediated Killing of Tumor Cells, Namita Varudkar

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Computational Strain Analysis in Microbiome Datasets with Application to Skin Disease, Minerva Fatimae Ventolero

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Intrahost Diversity of Staphylococcus aureus in Carriage among Native Americans, Julia Webb

Theses/Dissertations from 2021

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Downregulation of miR-34a via Calorie Restriction Regulates Lipid Metabolism in the Liver of Long-living Ames Dwarf Mice, Sarah Ashiqueali

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Investigating the Role of the Skeletal Muscle in Amyotrophic Lateral Sclerosis Neuromuscular Junction Dysfunction, Agnes Badu-Mensah

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Chitosan-Gallium Nanocomposite: Synthesis, Characterization and Antibacterial Activity, Samjhana Bhandari