Abstract
The next generation of system biology and drug discovery tools will be functional in vitro systems composed of human cells in defined serum-free systems. These functional in vitro systems will enable understanding beyond the single cell level directly to the human condition and enable the faster and least expensive translation of basic research to therapeutics. This study reports the first pure human-based in vitro Neuromuscular Junction (NMJ) system by demonstrating the co-culture of motoneurons and skeletal muscle (SKMs) derived from human stem cells, in a defined, serum-free medium and on a patternable non-biological surface.
Document Type
Patent
Patent Number
US 8,835,168
Application Serial Number
13/696,396
Issue Date
9-16-2014
Current Assignee
UCFRF
Assignee at Issuance
UCFRF
College
NanoScience Technology Center
Department
NanoScience Technology Center
Allowance Date
5-7-2014
Filing Date
11-6-2012
Assignee at Filing
UCFRF
Filing Type
National Filing Record
Donated
no
Recommended Citation
Hickman, James and Guo, Xiufang, "Synthetic mammalian neuromuscular junction and method of making (US)" (2014). UCF Patents. 558.
https://stars.library.ucf.edu/patents/558