Synthesis and biological activity of a series of highly functionalized phenylamdes

Keywords

Phenylamide derivatives, Alkyl chain length variation, Terminal alkyl-amide functionalization, Antifungal and antibacterial bioassays, Structure-activity relationship screening

Abstract

This report deals with the synthesis, characterization, and biological activity of a series of phenylamides possessing alkyl chains of varying length as well as additional alkyl amide moieties at the chain terminus. These compounds were targeted because of their expected activity against a specific fungus. The characterization and biological activity of many of the key intermediates are also reported. The biological activity of both the target compounds and the intermediates was determined by antibacterial and antifungal assays employing standard microbiological methodology. A total of thirty-two compounds were prepared and characterized; twenty-six of these were assayed. Several compounds displayed interesting activity in these screens.

Notes

This item is only available in print in the UCF Libraries. If this is your thesis or dissertation, you can help us make it available online for use by researchers around the world by STARS for more information.

Graduation Date

1991

Semester

Summer

Advisor

Gupton, John T.

Degree

Master of Science (M.S.)

College

College of Arts and Sciences

Department

Chemistry

Format

PDF

Pages

203 pages

Language

English

Length of Campus-only Access

None

Access Status

Masters Thesis (Open Access)

Identifier

DP0028675

Subjects

Arts and Sciences -- Dissertations; Academic; Dissertations; Academic -- Arts and Sciences; Fungicides--Synthesis; Antifungal agents--Evaluation; Organic compounds--Synthesis--Research; Phenyl compounds; Organic compounds--Structure-activity relationships

This document is currently not available here.

Share

COinS
 

Accessibility Statement

This item was created or digitized prior to April 24, 2026, or is a reproduction of legacy media created before that date. It is preserved in its original, unmodified state specifically for research, reference, or historical recordkeeping. In accordance with the ADA Title II Final Rule, the University Libraries provides accessible versions of archival materials upon request. To request an accommodation for this item, please submit an accessibility request form.