Applications of sodium perborate as an oxidant for organic substrates

Keywords

Sodium perborate-mediated oxidations, Epoxidation of alpha, beta-unsaturated ketones, Oxidative conversion of aryl nitriles to aryl amides, Mercury(II)-catalyzed oxidation of terminal alkynes, Hydrogen peroxide alternative oxidants

Abstract

The reactivity of sodium perborate toward a variety of organic substrates has been investigated. The reagent has been found to be an effective oxidant for the conversion of aryl nitriles to aryl amides, and a.,B -unsaturated ketones to the corresponding epoxyketones. The mercury(II)-catalyzed, sodium perborate oxidation of terminal alkynes has been found to result in smooth conversion of the substrates to 1-acetoxy-2-ketones. Thus, the reactivity of sodium perborate is believed to parallel that of hydrogen peroxide, both in basic and acidic media. In view of the safety and low cost of the reagent, sodium perborate is an attractive alternative to hydrogen peroxide in a variety of oxidative transformations of organic compounds.

Notes

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Graduation Date

1990

Semester

Spring

Advisor

Gupton, John T.

Degree

Master of Science (M.S.)

College

College of Arts and Sciences

Department

Chemistry

Format

PDF

Pages

111 pages

Language

English

Length of Campus-only Access

None

Access Status

Masters Thesis (Open Access)

Identifier

DP0027732

Subjects

Arts and Sciences -- Dissertations; Academic; Dissertations; Academic -- Arts and Sciences; Peroxides; Oxidizing agents; Borates; Oxidation--Research; Organic compounds--Reactivity

Accessibility Status

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