Title

Comparison Of The Effects Of Pathogenic Simian Human Immunodeficiency Virus Strains Shiv-89.6P And Shiv-Ku2 In Cynomolgus Macaques

Abstract

Factors explaining why human immunodeficiency virus (HIV) enhances the risk of reactivated tuberculosis (TB) are poorly understood. Unfortunately, experimental models of HIV-induced reactivated TB are lacking. We examined whether cynomolgus macaques, which accurately model latent TB in humans, could be used to model pathogenesis of HIV infection in the lungs and associated lymph nodes. These experiments precede studies modeling the effects of HIV infection on latent TB. We infected two groups of macaques with chimeric simian-human immunodeficiency viruses (SHIV-89.6P and SHIV-KU2) and followed viral titers and immunologic parameters including lymphocytes numbers and phenotype in the blood, bronchoalveolar lavage cells, and lymph nodes over the course of infection. Tissues from the lungs, liver, kidney, spleen, and lymph nodes were similarly examined at necropsy. Both strains produced dramatic CD4+ T cell depletion. Plasma titers were not different between viruses, but we found more SHIV-89.6P in the lungs. Both viruses induced similar patterns of cell activation markers. SHIV-89.6P induced more IFN-γ expression than SHIV-KU2. These results indicate SHIV-89.6P and SHIV-KU2 infect cynomolgus macaques and may be used to accurately model effects of HIV infection on latent TB. © 2008 Mary Ann Liebert, Inc.

Publication Date

4-1-2008

Publication Title

AIDS Research and Human Retroviruses

Volume

24

Issue

4

Number of Pages

643-654

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1089/aid.2007.0238

Socpus ID

42449114492 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/42449114492

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