Title

Evolution Of Drosophila Ribosomal Protein Gene Core Promoters

Keywords

Evolution; Motif; Promoter; Ribosomal protein

Abstract

The coordinated expression of ribosomal protein genes (RPGs) has been well documented in many species. Previous analyses of RPG promoters focus only on Fungi and mammals. Recognizing this gap and using a comparative genomics approach, we utilize a motif-finding algorithm that incorporates cross-species conservation to identify several significant motifs in Drosophila RPG promoters. As a result, significant differences of the enriched motifs in RPG promoter are found among Drosophila, Fungi, and mammals, demonstrating the evolutionary dynamics of the ribosomal gene regulatory network. We also report a motif present in similar numbers of RPGs among Drosophila species which does not appear to be conserved at the individual RPG gene level. A module-wise stabilizing selection theory is proposed to explain this observation. Overall, our results provide significant insight into the fast-evolving nature of transcriptional regulation in the RPG module. © 2008 Elsevier B.V. All rights reserved.

Publication Date

3-1-2009

Publication Title

Gene

Volume

432

Issue

1-2

Number of Pages

54-59

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.gene.2008.10.025

Socpus ID

58549089480 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/58549089480

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