Title

Prostasin Inhibits Cell Invasion In Human Choriocarcinomal Jeg-3 Cells

Keywords

Cell invasion; Choriocarcinomal JEG-3 cell; Integrins; MMPs/TIMPs; Prostasin

Abstract

Controlled invasion of the uterine wall by the trophoblast cells is pivotal for the successful pregnancy, and various kinds of protease are involved in this process. Serine protease prostasin has been shown to participate in the proteolytic activation of epithelial sodium channel as well as cleavage of epidermal growth factor receptor extracellular domain in human epithelial cells. Its physiological significance in human placentation has been suggested but not validated. In the present study, we found that prostasin was expressed at a relatively high level in human placenta trophoblasts in early pregnant weeks. In the in vitro cultured human choriocarcinomal JEG-3 cells, treatment with functional antibody against prostasin led to promotion in cell invasion capability, as well as increase in the production of MMP-2, MMP-26, TIMP-1, and TIMP-4. Our data indicated that this serine protease may function as an invasion suppressor in human trophoblast, participating in the invasion-restrictive regulation of trophoblasts to avoid their over-penetration into the uterine wall. © 2009 Springer-Verlag.

Publication Date

12-1-2009

Publication Title

Histochemistry and Cell Biology

Volume

132

Issue

6

Number of Pages

639-646

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s00418-009-0652-7

Socpus ID

71349088665 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/71349088665

This document is currently not available here.

Share

COinS