Title

Death And Baxes: Mechanisms Of Lymphotrophic Cytokines

Abstract

In this review, we briefly cover the critical requirements for interleukin-7 (IL-7) in thymocyte development and peripheral T-cell homeostasis. Part of the IL-7 effect is antiapoptotic or 'trophic' and we have studied the intracellular pathways involved in lymphocyte survival and death regulated by this cytokine. We review the evidence for a role of the JAK signal transducers and activators of transcription protein (STAT) pathway and phosphoinositide 3-kinase (PI3K)-AKT pathways in survival. The death pathway following IL-7 withdrawal is discussed in terms of the balance of BCL-2 vs. BAX and other death proteins and the role of metabolic disturbances involving glucose metabolism and intracellular pH. The IL-7 survival and death pathways in lymphocytes may be representative of many trophic factors in different cell types: yet we conclude that much of the mechanism remains to be discovered.

Publication Date

6-1-2003

Publication Title

Immunological Reviews

Volume

193

Number of Pages

48-57

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1034/j.1600-065X.2003.00050.x

Socpus ID

0037833701 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0037833701

This document is currently not available here.

Share

COinS