Title

Field-Induced Reorganization Of The Neural Membrane Lipid Bilayer: A Proposed Role In The Regulation Of Ion-Channel Dynamics

Keywords

Electrical signaling; Electrostatic interactions; Field-induced reorganization; Neural signaling

Abstract

We present a computational model demonstrating that an electric field propagating in the plane of the neural membrane during transmembrane ion movement creates lateral concentration gradients of the lipids. Due to this field-induced reorganization, ethenes of the lipid chains become aligned and polarized. This finding is interpreted within the context of molecular studies of protein folding in biological membranes. We propose that electrostatic interactions between membrane dipoles and charged amino acid residues of the unfolded ion-channel protein regulate protein-folding kinetics (channel closing). These electrostatic interactions thus regulate electrical signaling in neurons. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Publication Date

1-1-2003

Publication Title

BioSystems

Volume

68

Issue

1

Number of Pages

67-77

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/S0303-2647(02)00158-2

Socpus ID

0037245349 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0037245349

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