Title

Features Of Reovirus Outer Capsid Protein Μ1 Revealed By Electron Cryomicroscopy And Image Reconstruction Of The Virion At 7.0 Å Resolution

Abstract

Reovirus is a useful model for addressing the molecular basis of membrane penetration by one of the larger nonenveloped animal viruses. We now report the structure of the reovirus virion at 7.0 Å resolution as obtained by electron cryomicroscopy and three-dimensional image reconstruction. Several features of the myristoylated outer capsid protein μ1, not seen in a previous X-ray crystal structure of the μ1-σ3 heterohexamer, are evident in the virion. These features appear to be important for stabilizing the outer capsid, regulating the conformational changes in μ1 that accompany perforation of target membranes, and contributing directly to membrane penetration during cell entry. © 2005 Elsevier Ltd. All rights reserved.

Publication Date

10-1-2005

Publication Title

Structure

Volume

13

Issue

10

Number of Pages

1545-1557

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.str.2005.07.012

Socpus ID

26444511104 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/26444511104

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