Title

Neural Membrane Field Effects In A Cytoskeleton Corral: Microdomain Regulation Of Impulse Propagation

Keywords

Conduction failure; Cytoskeleton; Membranes; Microdomains; Rafts

Abstract

This article proposes that electrostatic interaction between transiently polarized neural-membrane ethenes and charged residues of an unfolded ion-channel protein regulate channel closing and electrical signaling in neurons. Field effects are confined by a cytoskeleton corral that gates movement of membrane lipids from one corralled region to another. Cytoskeleton gating permits stepwise changes in the concentration of unsaturated lipids and thereby modulates ion-channel activity. The system is hypothesized to operate at axonal branch points where impulse conduction has a low safety factor. Throughout the discussion the A-current delayed-rectifier potassium channel is used as an example. Implications of the model for molecular networks are briefly discussed. © 2004 Wiley Periodicals, Inc.

Publication Date

12-20-2004

Publication Title

International Journal of Quantum Chemistry

Volume

100

Issue

6

Number of Pages

1038-1046

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/qua.20257

Socpus ID

19944389276 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/19944389276

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