Title

Gd Nanoparticulates: From Magnetic Resonance Imaging To Neutron Capture Therapy

Keywords

Cancer; Dendrimer; Emulsions; Gadolinium; Liposomes; Magnetic resonance imaging; Nanoparticles; Neutron capture therapy

Abstract

Gadolinium (Gd) chelates have been extensively applied to enhance the imagery of anatomical tissues via magnetic resonance imaging (MRI). These molecular complexes have become some of the most common clinically applied contrast agents in modern medicine. The expansive development and clinical application of Gd chelates for MRI applications has led to a rebirth of interest in the use of Gd as a radiosensitizer in neutron capture therapy (NCT). However, the poor selective tissue labeling and localization provided by conventional molecular Gd chelates has limited success in both MRI and NCT applications. Methods for encapsulating Gd into nanoparticulate materials have been developed to overcome these limitations. Incorporating Gd chelates into nanoparticulate materials affords additional flexibility in engineering targeting and also provides a means to apply high tissue-centric concentrations of Gd - often critical for both imaging and therapeutic applications. The focus of this review is to summarize the evolution of engineered Gd nanoparticles, from self-assembled macromolecular structures to rigid particulate systems for enhanced MRI contrast and, separately, Gd NCT therapy. © 2007 VSP.

Publication Date

11-1-2007

Publication Title

Advanced Powder Technology

Volume

18

Issue

6

Number of Pages

663-698

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1163/156855207782515030

Socpus ID

36148957891 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/36148957891

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