Title

Auto-Catalytic Ceria Nanoparticles Offer Neuroprotection To Adult Rat Spinal Cord Neurons

Keywords

Adult spinal cord neurons; Auto-catalytic; Cerium oxide; Nanoparticle; Nerve regeneration; Neuroprotection

Abstract

This paper describes the evaluation of the auto-catalytic anti-oxidant behavior and biocompatibility of cerium oxide nanoparticles for applications in spinal cord repair and other diseases of the central nervous system. The application of a single dose of nano-ceria at a nano-molar concentration is biocompatible, regenerative and provides a significant neuroprotective effect on adult rat spinal cord neurons. Retention of neuronal function is demonstrated from electrophysiological recordings and the possibility of its application to prevent ischemic insult is suggested from an oxidative injury assay. A mechanism is proposed to explain the auto-catalytic properties of these nanoparticles. © 2006 Elsevier Ltd. All rights reserved.

Publication Date

4-1-2007

Publication Title

Biomaterials

Volume

28

Issue

10

Number of Pages

1918-1925

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.biomaterials.2006.11.036

Socpus ID

33846314024 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/33846314024

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