Title

Reduction Of Noise-Induced Hearing Loss Using L-Nac And Salicylate In The Chinchilla

Keywords

Antioxidant; Chinchilla; Evoked potential; Hair cell; Loud noise

Abstract

The effects of a combination of two antioxidant compounds were studied in a chinchilla model of noise-induced hearing loss. After obtaining baseline hearing thresholds using inferior colliculus evoked potentials, chinchillas were exposed for 6 h to octave band noise centered at 4 kHz (105 dB SPL). Post-noise thresholds were obtained 1 h after the noise exposure, and then animals received either saline or salicylate and N-L-acetylcysteine combination. Another group received antioxidant treatment 1 h prior to noise. Hearing was tested at 1, 2 and 3 weeks post-noise. Subsequently, the cochleae were harvested, and cytocochleograms were prepared. There was a 20-40 dB SPL threshold shift at 3 weeks for tested controls. Permanent threshold shifts (PTS) were significantly reduced (P<0.05) to approximately 10 dB for the pre-treatment group at week 3. The PTS for the post-treatment group at week 3 was similar to the pre-treatment group at 1 and 2 kHz (0-10 dB) but was intermediate between the control and pre-treatment groups at 4 and 8 kHz (23 dB). Animals pre-treated with antioxidant had a significant reduction in hair cell loss but those post-treated with antioxidant had no protection from hair cell loss. These findings demonstrate the feasibility of reduction of noise-induced hearing loss using clinically available antioxidant compounds. Copyright (C) 2000 Elsevier Science B.V.

Publication Date

10-13-2000

Publication Title

Hearing Research

Volume

149

Issue

1-2

Number of Pages

138-146

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/S0378-5955(00)00176-3

Socpus ID

0033805864 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/0033805864

This document is currently not available here.

Share

COinS