Title

Chloroplast-Derived Anthrax And Other Vaccine Antigens: Their Immunogenic And Immunoprotective Properties

Keywords

Anthrax vaccine; Chloroplast genetic engineering; Genetically modified crops; Immunization; Mucosal immunity; Oral delivery; Protective antigens; Systemic immunity; Vaccines

Abstract

Transgenic plants offer many advantages, including low cost of production (by elimination of fermenters), storage and transportation, heat stability, absence of human pathogens, protection of antigens in the stomach through bioencapsulation (when delivered orally), elimination of the need for expensive purification and sterile injections and generation of both systemic and mucosal immunity. Recent studies have demonstrated that chloroplast-derived anthrax-protective antigen elicits effective immune responses, develops neutralizing antibodies, confers complete protection against anthrax lethal toxin challenge and produces 360 million doses of vaccine in one acre of transgenic plants. Chloroplast-derived vaccine antigens are efficacious against bacterial, fungal, viral and protozoan pathogens. © 2006 Future Drugs Ltd.

Publication Date

12-1-2006

Publication Title

Expert Review of Vaccines

Volume

5

Issue

6

Number of Pages

839-849

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1586/14760584.5.6.839

Socpus ID

33845894440 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/33845894440

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