Title

Amyloid Precursor Protein Regulates Differentiation Of Human Neural Stem Cells

Abstract

Although amyloid β (Aβ) deposition has been a hallmark of Alzheimer's disease (AD), the absence of a phenotype in the β amyloid precursor protein (APP) knockout mouse, tends to detract our attention away from the physiological functions of APP. Although much attention has been focused on the neurotoxicity of Aβ, many studies suggest the involvement of APP in neuroplasticity. We found that secreted amyloid precursor protein (sAPP) increased the differentiation of human neural stem cells (hNSCs) in vitro, while an antibody-recognizing APP dose-dependently inhibited these activities. With a high dose of sAPP treatment or wild-type APP gene transfection, hNSCs were differentiated into astrocytes rather than neurons. In vivo, hNSCs transplanted into APP-transgenic mouse brain exhibited glial differentiation rather than neural differentiation. Our results suggest that APP regulates neural stem cell biology in the adult brain, and that altered APP metabolism in Down syndrome or AD may have implications for the pathophysiology of these diseases. © Mary Ann Liebert, Inc.

Publication Date

6-1-2006

Publication Title

Stem Cells and Development

Volume

15

Issue

3

Number of Pages

381-389

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1089/scd.2006.15.381

Socpus ID

33746216955 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/33746216955

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