Title

Cell Cycling Through Cdc25A: Transducer Of Cytokine Proliferative Signals

Keywords

Cdc25A; Cell cycle; Cytokine; Growth arrest; Homeostasis; Interleukin-7; Lymphocyte; p38 MAPK; p7kip1; Proliferation

Abstract

A balance between survival and proliferative signals maintains a constant number of T lymphocytes that populate the mammalian immune system, a process termed "homeostasis". Central to this process is the availability of a stromal cell product - the cytokine interleukin-7 (IL-7). We recently showed that IL-7, in addition to protecting cells from apoptosis, drives the cell cycling of lymphocytes through regulation of the stability of the phosphatase, Cdc25A, a key activator of cyclin-dependent kinases (cdks). IL-7 achieves this by controlling the activity of p38 MAP kinase (MAPK), which can phosphorylate Cdc25A, triggering its degradation. Sustained expression of Cdc25A had diverse effects: it promoted cell cycling, even in presence of cell cycle inhibitors such p27Kip1, and prevented cell shrinkage in response to cytokine deprivation. Herein we show a role for Cdc25A as a transducer of cytokine-driven proliferation and discuss novel implications for cell growth from the perspective of the requirements for maintenance of lymphocyte homeostasis. ©2006 Landes Bioscience.

Publication Date

5-1-2006

Publication Title

Cell Cycle

Volume

5

Issue

9

Number of Pages

907-912

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.4161/cc.5.9.2693

Socpus ID

33646422508 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/33646422508

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