Title

Enhanced Imaging And Accelerated Photothermalysis Of A549 Human Lung Cancer Cells By Gold Nanospheres

Keywords

Cancer; Gold nanoparticles; Laser; Photothermal therapy; Photothermalysis; Viability

Abstract

Background & aims: Gold nanoparticles are excellent photon-thermal energy converters. The purpose of this work was to investigate the influence of gold nanoparticles on the photothermalysis of A549 lung tumor cells. Materials & methods: A549 lung tumor cells were exposed to goat antihuman immunoglobulin (lg)G-conjugated gold nanospheres (40 nm) and were then imaged under a dark-field microscope. The live cells were then subjected to photoirradiation-using a 633-nm laser at different power levels. The viability of tumor cells under laser irradiation was monitored by confocal microscopy using a viability-assay kit. Results & discussion: The death rates of A549 lung tumor cells after gold nanoparticle exposure increased significantly under laser irradiation. The maximum initial cell death rate was observed at a laser power level of 3.75 mW, with the initial deactivation rate accelerated by a factor of 6.6 and a total loss of 92% of cell viability. Conclusion: This work demonstrated potential applications of gold nanospheres as both imaging probes and enhancing agents for photothermal therapy of cancer. © 2008 Future Medicine Ltd.

Publication Date

10-1-2008

Publication Title

Nanomedicine

Volume

3

Issue

5

Number of Pages

617-626

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.2217/17435889.3.5.617

Socpus ID

55949132140 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/55949132140

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