Title

Whole Genome Identification Of Target Genes Of Transcription Factors

Keywords

Phylogenetic footprinting; Position weight matrix; Transcription factor binding sites

Abstract

It is important to develop computational methods to predict target genes of a transcription factor. In this paper, we developed a phylogenetic footprinting method to effectively identify target genes on the whole genome scale. Appling the method to 31 transcription factors, we improved the quality of the initial motifs, and predicted additional target genes that are supported by gene ontology analysis. We also showed that the predicted target genes of different transcription factors could provide evidences of cooperation to form transcription modules. Our method provides useful tools for systematic study of gene regulatory networks. © 2010 IEEE.

Publication Date

7-16-2010

Publication Title

ICBBT 2010 - 2010 International Conference on Bioinformatics and Biomedical Technology

Number of Pages

27-30

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1109/ICBBT.2010.5479016

Socpus ID

77954488551 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/77954488551

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