Title
Whole Genome Identification Of Target Genes Of Transcription Factors
Keywords
Phylogenetic footprinting; Position weight matrix; Transcription factor binding sites
Abstract
It is important to develop computational methods to predict target genes of a transcription factor. In this paper, we developed a phylogenetic footprinting method to effectively identify target genes on the whole genome scale. Appling the method to 31 transcription factors, we improved the quality of the initial motifs, and predicted additional target genes that are supported by gene ontology analysis. We also showed that the predicted target genes of different transcription factors could provide evidences of cooperation to form transcription modules. Our method provides useful tools for systematic study of gene regulatory networks. © 2010 IEEE.
Publication Date
7-16-2010
Publication Title
ICBBT 2010 - 2010 International Conference on Bioinformatics and Biomedical Technology
Number of Pages
27-30
Document Type
Article; Proceedings Paper
Personal Identifier
scopus
DOI Link
https://doi.org/10.1109/ICBBT.2010.5479016
Copyright Status
Unknown
Socpus ID
77954488551 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/77954488551
STARS Citation
Hu, Haiyan and Li, Xiaoman, "Whole Genome Identification Of Target Genes Of Transcription Factors" (2010). Scopus Export 2010-2014. 1062.
https://stars.library.ucf.edu/scopus2010/1062