Title

The Trna Synthetase Paralog Poxa Modifies Elongation Factor-P With (R)-Β-Lysine

Abstract

The lysyl-tRNA synthetase paralog PoxA modifies elongation factor P (EF-P) with α-lysine at low efficiency. Cell-free extracts containing non-α-lysine substrates of PoxA modified EF-P with a change in mass consistent with addition of β -lysine, a substrate also predicted by genomic analyses. EF-P was efficiently functionally modified with (R)-β-lysine but not (S)-β-lysine or genetically encoded α-amino acids, indicating that PoxA has evolved an activity orthogonal to that of the canonical aminoacyl-tRNA synthetases. © 2011 Nature America, Inc. All rights reserved.

Publication Date

1-1-2011

Publication Title

Nature Chemical Biology

Volume

7

Issue

10

Number of Pages

667-669

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1038/nchembio.632

Socpus ID

80052963243 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/80052963243

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