Title

Computational Analysis And Structure Predictions Of Chh-Related Peptides From Litopenaeus Vannamei

Abstract

The crustaceans produce several related peptides that belong to the crustacean hyperglycemic hormone (CHH) family. While these peptides have similar amino acid sequences, they have diverse biological functions that must arise, in part, from differences in the 3D shape of these peptides. However, it is generally accepted that peptides with a high degree of sequence similarity also have a similar 3-D structure. We used the solution structure of one peptide in the crustacean hyperglycemic hormone family, the molt-inhibiting hormone of the kuruma prawn (Marsupenaeus japonicus), to predict the shape of the five known peptides related to CHH in the Pacific white shrimp, Litopenaeus vannamei. The high similarity of the 3-D structures of these peptides suggests a common fold for the entire family. Nevertheless, minor differences in the shape of these peptides were observed, which may be the basis for their different biological properties. © 2011 The Royal Society of Chemistry.

Publication Date

3-1-2011

Publication Title

Integrative Biology

Volume

3

Issue

3

Number of Pages

218-224

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/c0ib00086h

Socpus ID

79952509463 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/79952509463

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