Title

Harnessing Nanoparticles To Improve Toxicity After Head And Neck Radiation

Keywords

Cerium oxide nanoparticles; Nanoparticle; Radiation-induced toxicity; Radioprotection; Radiotherapy; Xerostomia

Abstract

This article reports the evaluation of cerium oxide (CeO2) nanoparticles' ability to decrease xerostomia and radiation-induced dermatitis in mice after head and neck radiation. Mice were irradiated using an IC160 x-ray system. Two cohorts were included: (A) No-radiation and (B) 30 Gy/6 fractions, and were randomized into three groups: (1) saline, (2) 15 nM CeO2 and (3) 15 μM CeO2. Stimulated salivary flow and radiation-induced dermatitis were evaluated post radiation. Stimulated sialometry demonstrated improved salivary production in all CeO2 groups in comparison with controls (flow: 204 vs. 115 μL/10 minutes, P = 0.0002). One week post radiation, G-III dermatitis decreased in the 15 μM group in comparison with controls (10% versus 100% incidence, respectively). There was decreased skin hyperpigmentation at 12 weeks in the 15-μM group in comparison with 15-nM and non-CeO2 groups (50%, 70%, and 90% G-II, respectively). This study suggests that CeO2 may be radioprotective for salivary production and reduces G-III dermatitis and skin hyperpigmentation incidence. CeO2 as radioprotectant may be a feasible concept during radiotherapy. From the Clinical Editor: This study demonstrates in a mouse model that cerium oxide (CeO2) nanoparticles may provide an important mechanism in preventing radiation induced xerostomia, a common complication of head and neck radiation treatments. © 2012 Elsevier Inc.

Publication Date

10-1-2012

Publication Title

Nanomedicine: Nanotechnology, Biology, and Medicine

Volume

8

Issue

7

Number of Pages

1223-1231

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.nano.2011.12.011

Socpus ID

84866524453 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84866524453

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