Title

Leptin And Leptin Receptor Genetic Variants Associate With Habitual Physical Activity And The Arm Body Composition Response To Resistance Training

Keywords

Exercise; Genomics; Polymorphism

Abstract

Purpose: We investigated the influence of Leptin (LEP) and leptin receptor (LEPR) SNPs on habitual physical activity (PA) and body composition response to a unilateral, upper body resistance training (RT) program. Methods: European-derived American volunteers (men=111, women=131, 23.4±5.4yr, 24.4±4.6kg·m-2) were genotyped for LEP 19 G>A (rs2167270), and LEPR 326 A>G (rs1137100), 668 A>G (rs1137101), 3057 G>A (rs1805096), and 1968 G>C (rs8179183). They completed the Paffenbarger PA Questionnaire. Arm muscle and subcutaneous fat volumes were measured before and after 12wk of supervised RT with MRI. Multivariate and repeated measures ANCOVA tested differences among phenotypes by genotype and gender with age and body mass index as covariates. Results: Adults with the LEP 19 GG genotype reported more kcal/wk in vigorous intensity PA (1273.3±176.8, p=0.017) and sports/recreation (1922.8±226.0, p<0.04) than A allele carriers (718.0±147.2, 1328.6±188.2, respectively). Those with the LEP 19 GG genotype spent more h/wk in light intensity PA (39.7±1.6) than A allele carriers (35.0±1.4, p=0.03). In response to RT, adults with the LEPR 668 G allele gained greater arm muscle volume (67,687.05±3186.7 vs. 52,321.87±5125.05mm3, p=0.01) and subcutaneous fat volume (10,599.89±3683.57 vs. -5224.73±5923.98mm3, p=0.02) than adults with the LEPR 668 AA genotype, respectively. Conclusion: LEP19 G>A and LEPR 668 A>G associated with habitual PA and the body composition response to RT. These LEP and LEPR SNPs are located in coding exons likely influencing LEP and LEPR function. Further investigation is needed to confirm our findings and establish mechanisms for LEP and LEPR genotype and PA and body composition associations we observed. © 2012 Elsevier B.V.

Publication Date

11-15-2012

Publication Title

Gene

Volume

510

Issue

1

Number of Pages

66-70

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.gene.2012.08.020

Socpus ID

84866890917 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84866890917

This document is currently not available here.

Share

COinS