Title

Total Earth Pressure Cells For Measuring Loads In A Municipal Solid Waste Landfill

Keywords

JNK; Macrophage; NF-κB; Signal transduction; Toll-like receptor

Abstract

Toll-like receptors (TLR) are pivotal in macrophage activation. The molecular mechanisms controlling TLR signaling and macrophage activation are not completely understood. Zc3h12d is originally identified as a possible tumor suppressor gene. However, its function remains unknown. We here report that Zc3h12d negatively regulates TLR signaling and macrophage activation. Zc3h12d was enriched in spleen, lung and lymph node. In macrophages, the expression of Zc3h12d was remarkably induced by TLR ligands through JNK and NF-κB signal pathways. On the other hand, overexpression of Zc3h12d significantly inhibited TLR2 and TLR4 activation-induced JNK, ERK and NF-κB signaling as well as macrophage inflammation. Similar to Zc3h12a/MCPIP1, Zc3h12d also decreased the global cellular protein ubiquitination. These findings suggest that Zc3h12d is a novel negative feedback regulator of TLR signaling and macrophage activation and thus may play a role in host immunity and inflammatory diseases. © 2011 Elsevier Inc..

Publication Date

2-1-2012

Publication Title

Geotechnical and Geological Engineering

Volume

30

Issue

2

Number of Pages

95-105

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s10706-011-9452-7

Socpus ID

84155189667 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84155189667

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