Title

Applying The Modality Principle To Real-Time Feedback And The Acquisition Of Higher-Order Cognitive Skills

Keywords

CRMP5; Paraneoplastic neurologic syndromes; Peripheral neuropathy; Schwann cells

Abstract

Collapsin response mediator protein 5 (CRMP5) is one of the rare peripheral nerve antigens that is a target of autoantibodies in a paraneoplastic peripheral neuropathy. The pattern of axonal and myelin alterations suggests that CRMP5 is involved in axon-Schwann cellinteraction. We examined CRMP5 expression and function in primary cultures of Schwann cells and neurons and at various developmentaland regenerating stages of rat sciatic nerve and in CRMP5-deficient mice in vivo. Collapsin response mediator protein 5 was strongly expressed during postnatal development and regeneration and decreased with myelination. It was mainly expressed by immature Schwann cells and persisted in Remak cells in the adult; however, a subpopulation of Schwann cells that were induced to myelinate also expressed CRMP5. We identified 2 axonal molecular cues regulating CRMP5 expression: human neuregulin type 1, which induces CRMP5 expression in immature and premyelinating Schwann cells, and cyclic adenosine monophosphate, which inhibits CRMP5 expression when Schwann cells begin myelination. Collapsin response mediator protein 5-deficient mice showed abnormal Schwann process extension resulting in abnormal cell-axon segregation, indicating that CRMP5 is involved in the morphologic adaptation of Schwann cells to surround axons. These results demonstrate the importance of CRMP5 in axon-Schwann cell cooperation during development and regeneration. © 2012 American Association of Neuropathologists, Inc.

Publication Date

4-1-2012

Publication Title

Educational Technology Research and Development

Volume

60

Issue

4

Number of Pages

223-238

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s11423-011-9218-1

Socpus ID

84859101451 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84859101451

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