Title

Herpes Zoster Complicating Bortezomib Therapy Of Relapsed/Refractory Indolent B-Cell And Mantle Cell Lymphoma: An Analysis Of Two Phase Ii Trials

Keywords

Bortezomib; Herpes zoster; Mantle cell lymphoma; Non-Hodgkin lymphoma

Abstract

The incidence of herpes zoster (HZ) in patients with non-Hodgkin lymphoma (NHL) receiving bortezomib-based therapy has not been well studied. We reviewed data from two phase II trials in which bortezomib was administered to 236 patients, median age 65 years, with relapsed/refractory mantle cell or indolent NHL. HZ occurred in 24 patients (10.2%) overall, with a comparable incidence in NHL histologic subgroups. Median time to HZ was 39 (range, 11-206) days. In total, 71% of patients who developed HZ were aged ≥ 65 years, compared to 48% without HZ (p = 0.03). Patients with HZ were more likely to have had received ≥ 2 lines of therapy (63% vs. 47%, p = 0.16). Six (25%) of the patients who developed HZ had received purine analogs, compared with 34 (16%) patients without HZ (p = 0.27). As the occurrence of HZ may complicate the course of indolent or mantle cell NHL in patients receiving bortezomib-based therapies, these patients, especially the elderly, should be strongly considered for antiviral prophylaxis. © 2013 Informa UK, Ltd.

Publication Date

10-1-2013

Publication Title

Leukemia and Lymphoma

Volume

54

Issue

10

Number of Pages

2185-2189

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.3109/10428194.2013.772294

Socpus ID

84884497738 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84884497738

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