Title

Post-Synthetic Chemical Functionalization Of Oligonucleotides

Keywords

Amide; Cycloaddition; Disulfide; Hydrazone; Native chemical ligation; Oligonucleotide conjugation; Oxime; Photo-induced reaction; Thioether; Transferases

Abstract

The rapidly growing interest in synthetic oligonucleotides originates from their capability to regulate gene expressions, their high binding affinity to molecular targets, and their ability to exert enzymatic functions. However, the therapeutic and diagnostic applications of oligonucleotides are limited by their intrinsic properties. To address these challenges, chemical modifications have been applied to oligonucleotides to achieve greater potency, enhanced stability, and desired bioavailability. This chapter focuses on the major protocols developed in recent years for oligonucleotide postsynthetic modifications and provides detailed examples of each reaction category along with the relevant applications of the resulting oligonucleotide conjugates. © 2014 Elsevier Ltd. All rights reserved.

Publication Date

1-1-2014

Publication Title

Comprehensive Organic Synthesis: Second Edition

Volume

9

Number of Pages

463-493

Document Type

Article; Book Chapter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/B978-0-08-097742-3.00908-3

Socpus ID

84903493143 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84903493143

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