Enhancing The Sensitivity Of Colorimetric Lateral Flow Assay (Clfa) Through Signal Amplification Techniques

Abstract

Colorimetric lateral flow assay (CLFA) is one of a handful of diagnostic technologies that can be truly taken out of the laboratory for point-of-care testing without the need for any equipment and skilled personnel. Despite its simplicity and practicality, it remains a grand challenge to substantially enhance the detection sensitivity of CLFA without adding complexity. Such a limitation in sensitivity inhibits many critical applications such as early detection of significant cancers and severe infectious diseases. With the rapid development of materials science and nanotechnology, signal amplification techniques that hold great potential to break through the existing detection limit barrier of CLFA have been developed in recent years. This article specifically highlights these emerging techniques for CLFA development. The rationale behind and advantages and limitations of each technique are discussed. Perspectives on future research directions in this niche and important field are provided.

Publication Date

1-1-2018

Publication Title

Journal of Materials Chemistry B

Volume

6

Issue

44

Number of Pages

7102-7111

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/C8TB01603H

Socpus ID

85056619563 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85056619563

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