Title

Effect Of Gravity On Subject-Specific Human Lung Deformation

Keywords

biomechanical model; finite element analysis; gravity; Human lung deformation

Abstract

A biomechanical model of human lung is developed and used to investigate the effect of gravity on lung deformation. The lung is assumed to behave as a poro-elastic medium with spatially dependent elastic property. Finite element analysis is performed on a three-dimensional (3D) lung geometry reconstructed from a four-dimensional Computed Tomography (4DCT) scan dataset of human patient. The spatially dependent Young’s modulus (YM) values are estimated using inverse analysis from a linear elastic deformation model. The predicted deformation of selected landmarks is monitored with and without gravity, and compared with data obtained from 4DCT registration. The results show that gravity indeed significantly affects the magnitude and distribution of lung deformation with the maximum displacement enhanced by 54% in the direction of gravity, for the conditions investigated. In summary, the accuracy of predicted deformation is improved through incorporation of gravity in the biomechanical model of lung.

Publication Date

1-2-2018

Publication Title

Mathematical and Computer Modelling of Dynamical Systems

Volume

24

Issue

1

Number of Pages

87-101

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1080/13873954.2017.1382537

Socpus ID

85030167006 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85030167006

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