Charge Splitters And Charge Transport Junctions Based On Guanine Quadruplexes

Abstract

Self-assembling circuit elements, such as current splitters or combiners at the molecular scale, require the design of building blocks with three or more terminals. A promising material for such building blocks is DNA, wherein multiple strands can self-assemble into multi-ended junctions, and nucleobase stacks can transport charge over long distances. However, nucleobase stacking is often disrupted at junction points, hindering electric charge transport between the two terminals of the junction. Here, we show that a guanine-quadruplex (G4) motif can be used as a connector element for a multi-ended DNA junction. By attaching specific terminal groups to the motif, we demonstrate that charges can enter the structure from one terminal at one end of a three-way G4 motif, and can exit from one of two terminals at the other end with minimal carrier transport attenuation. Moreover, we study four-way G4 junction structures by performing theoretical calculations to assist in the design and optimization of these connectors.

Publication Date

4-1-2018

Publication Title

Nature Nanotechnology

Volume

13

Issue

4

Number of Pages

316-321

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1038/s41565-018-0070-x

Socpus ID

85042534123 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85042534123

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