Myeloid Leukemias And Virally Induced Lymphomas In Miniature Inbred Swine: Development Of A Large Animal Tumor Model

Keywords

Cancer; CML; Model; PTLD; Swine; Transplantation immunology

Abstract

The lack of a large animal transplantable tumor model has limited the study of novel therapeutic strategies for the treatment of liquid cancers. Swine as a species provide a natural option based on their similarities with humans and their already extensive use in biomedical research. Specifically, the Massachusetts General Hospital miniature swine herd retains unique genetic characteristics that facilitate the study of hematopoietic cell and solid organ transplantation. Spontaneously arising liquid cancers in these swine, specifically myeloid leukemias and B cell lymphomas, closely resemble human malignancies. The ability to establish aggressive tumor cell lines in vitro from these naturally occurring malignancies makes a transplantable tumor model a close reality. Here, we discuss our experience with myeloid and lymphoid tumors in major histocompatibility characterized miniature swine and future approaches regarding the development of a large animal transplantable tumor model.

Publication Date

1-1-2015

Publication Title

Frontiers in Genetics

Volume

6

Issue

NOV

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.3389/fgene.2015.00332

Socpus ID

84954537341 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84954537341

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