Computational Analysis Of Rna Structures With Chemical Probing Data

Keywords

Chemical probing; Parallel sequencing; RNA secondary structure; RNA tertiary structure

Abstract

RNAs play various roles, not only as the genetic codes to synthesize proteins, but also as the direct participants of biological functions determined by their underlying high-order structures. Although many computational methods have been proposed for analyzing RNA structures, their accuracy and efficiency are limited, especially when applied to the large RNAs and the genome-wide data sets. Recently, advances in parallel sequencing and high-throughput chemical probing technologies have prompted the development of numerous new algorithms, which can incorporate the auxiliary structural information obtained from those experiments. Their potential has been revealed by the secondary structure prediction of ribosomal RNAs and the genome-wide ncRNA function annotation. In this review, the existing probing-directed computational methods for RNA secondary and tertiary structure analysis are discussed.

Publication Date

6-1-2015

Publication Title

Methods

Volume

79

Number of Pages

60-66

Document Type

Editorial Material

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.ymeth.2015.02.003

Socpus ID

84929379114 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84929379114

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