Total Synthesis Of Teixobactin

Abstract

To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.

Publication Date

8-3-2016

Publication Title

Nature Communications

Volume

7

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1038/ncomms12394

Socpus ID

84980564856 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84980564856

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