Title
Total Synthesis Of Teixobactin
Abstract
To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.
Publication Date
8-3-2016
Publication Title
Nature Communications
Volume
7
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1038/ncomms12394
Copyright Status
Unknown
Socpus ID
84980564856 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84980564856
STARS Citation
Jin, Kang; Sam, Iek Hou; Po, Kathy Hiu Laam; Lin, Du'An; and Ghazvini Zadeh, Ebrahim H., "Total Synthesis Of Teixobactin" (2016). Scopus Export 2015-2019. 2437.
https://stars.library.ucf.edu/scopus2015/2437