Improved Synthesis Of The Triazacryptand (Tac) And Its Application In The Construction Of A Fluorescent Tac-Bodipy Conjugate For K+ Sensing In Live Cells

Keywords

Cell imaging; Cryptands; Fluorescence; Potassium; Sensors

Abstract

In this report, a vastly improved method for the synthesis of [2.2.3]-triazacryptand (TAC), an excellent K+-selective cryptand, is disclosed, which provides a shorter synthetic route with > fivefold higher overall yield. On the basis of the improved synthesis, a TAC-BODIPY conjugate was developed for K+ sensing. TAC-BODIPY is a fluorescence turn-on K+ sensor exhibiting high selectivity toward K+ over other biologically relevant metal cations. Cell imaging studies are presented and demonstrate that TAC-BODIPY is suitable for dynamic K+ sensing in live cells.

Publication Date

1-1-2015

Publication Title

European Journal of Organic Chemistry

Volume

2015

Issue

6

Number of Pages

1189-1192

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/ejoc.201403600

Socpus ID

85027958851 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85027958851

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