Title
Improved Synthesis Of The Triazacryptand (Tac) And Its Application In The Construction Of A Fluorescent Tac-Bodipy Conjugate For K+ Sensing In Live Cells
Keywords
Cell imaging; Cryptands; Fluorescence; Potassium; Sensors
Abstract
In this report, a vastly improved method for the synthesis of [2.2.3]-triazacryptand (TAC), an excellent K+-selective cryptand, is disclosed, which provides a shorter synthetic route with > fivefold higher overall yield. On the basis of the improved synthesis, a TAC-BODIPY conjugate was developed for K+ sensing. TAC-BODIPY is a fluorescence turn-on K+ sensor exhibiting high selectivity toward K+ over other biologically relevant metal cations. Cell imaging studies are presented and demonstrate that TAC-BODIPY is suitable for dynamic K+ sensing in live cells.
Publication Date
1-1-2015
Publication Title
European Journal of Organic Chemistry
Volume
2015
Issue
6
Number of Pages
1189-1192
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1002/ejoc.201403600
Copyright Status
Unknown
Socpus ID
85027958851 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/85027958851
STARS Citation
Sui, Binglin; Yue, Xiling; Tichy, Michael G.; Liu, Taihong; and Belfield, Kevin D., "Improved Synthesis Of The Triazacryptand (Tac) And Its Application In The Construction Of A Fluorescent Tac-Bodipy Conjugate For K+ Sensing In Live Cells" (2015). Scopus Export 2015-2019. 256.
https://stars.library.ucf.edu/scopus2015/256